Lukash L L, Karpova I S, Miroshnichenko O S, Tikhonova T N, Lylo V V, Man'ko V G, Sukhorada E M, Golynskaia E L
Tsitol Genet. 1997 Sep-Oct;31(5):52-60.
Data on separation of purified galactose-specific lectin as well as its two polypeptide chains from inflorescences of European elder Sambucus nigra are represented. Their molecule quaternary structure after the pattern a2 b2 is suggested. It was shown that purified protein in concentration 2.0 mg/ml had mutagenic activity and might enhance mutagenic effect of alkylating substance MNNG. Thus, preparations of lectin from inflorescences of European elder influenced on spontaneous and induced by the alkylating agent mutagenicity in mammalian somatic cells in vitro.
文中展示了从欧洲接骨木（Sambucus nigra）花序中分离纯化的半乳糖特异性凝集素及其两条多肽链的数据。推测其分子四级结构为α2β2模式。结果表明，浓度为2.0毫克/毫升的纯化蛋白具有诱变活性，且可能增强烷化剂MNNG的诱变作用。因此，欧洲接骨木花序中的凝集素制剂会影响哺乳动物体细胞体外的自发诱变以及烷化剂诱导的诱变。
