Laros R K, Penner J A
Obstet Gynecol. 1976 Sep;48(3):353-6.
Our previous studies suggested that disseminated intravascular coagulation (DIC) may be a sequel to saline-induced abortion. A hypothetical mechanism for the DIC is that hypertonic saline produces cellular disruption in the products of conception with the release of thromboplastic substances into the amniotic fluid. These substances, in turn, diffuse through the damaged membranes into the maternal circulation. To examine this hypothesis we obtained samples of amniotic fluid (AF) from 5 patients just prior to and at 1 hour, 6 hours, and 24 hours after intraamniotic instillation of hypertonic saline. The procoagulant and thromboplastic properties of the various AF specimens were quantitated using the prothrombin time (PT), partial thromboplastin time (PTT), and activated clotting time (ACT) as in vitro test systems. The results indicate that a change in the procoagulant and/or thromboplastic activity of AF following saline instillation is not afactor in the pathophysiology of DIC associated with saline abortion.
我们之前的研究表明，弥散性血管内凝血（DIC）可能是盐水引产的后遗症。DIC的一种假说机制是高渗盐水导致妊娠产物中的细胞破裂，促凝物质释放到羊水中。这些物质继而通过受损的胎膜扩散到母体循环中。为验证这一假说，我们在5名患者羊膜腔内注入高渗盐水之前以及之后1小时、6小时和24小时采集羊水样本。使用凝血酶原时间（PT）、部分凝血活酶时间（PTT）和活化凝血时间（ACT）作为体外测试系统，对各种羊水样本的促凝和促凝血特性进行定量分析。结果表明，注入盐水后羊水促凝和/或促凝血活性的变化并非与盐水引产相关的DIC病理生理学中的一个因素。
