中间丝及其相关蛋白：多种动态特性

Intermediate filaments and their associated proteins: multiple dynamic personalities.

作者信息

Houseweart M K, Cleveland D W

机构信息

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla 92093, USA.

出版信息

Curr Opin Cell Biol. 1998 Feb;10(1):93-101. doi: 10.1016/s0955-0674(98)80091-4.

DOI:10.1016/s0955-0674(98)80091-4

PMID:9484600

Abstract

A fusion of mouse and human genetics has now proven that intermediate filaments form a flexible scaffold essential for structuring cytoplasm in a variety of cell contexts. In some cases, the formation of this scaffold is achieved through a newly identified family of intermediate-filament-associated proteins that form cross-bridges between intermediate filaments and other cytoskeletal elements, including actin and microtubules.

摘要

小鼠遗传学与人类遗传学的融合现已证明，中间丝形成了一种灵活的支架，对于在多种细胞环境中构建细胞质至关重要。在某些情况下，这种支架的形成是通过一个新发现的中间丝相关蛋白家族实现的，这些蛋白在中间丝与其他细胞骨架成分（包括肌动蛋白和微管）之间形成交叉桥。