Neven P, Vergote I
Algemene Kliniek St.-Jan, Department of Obstetrics and Gynaecology, Brussels, Belgium.
Curr Opin Obstet Gynecol. 1998 Feb;10(1):9-14. doi: 10.1097/00001703-199802000-00003.
An increasing number of cases of endometrial cancer in women receiving tamoxifen have been reported but most are from non-randomized studies and case reports. In the last year, there have been no further results either confirming or disproving an association between tamoxifen and endometrial cancer from randomized controlled studies in breast cancer patients and those participating in chemopreventative trials with tamoxifen. Several papers have examined the possible mechanisms behind tamoxifen's endometrial effects.
有报道称，接受他莫昔芬治疗的女性子宫内膜癌病例数在不断增加，但大多数来自非随机研究和病例报告。在过去的一年里，乳腺癌患者的随机对照研究以及参与他莫昔芬化学预防试验的研究中，均未得出进一步结果来证实或反驳他莫昔芬与子宫内膜癌之间的关联。有几篇论文探讨了他莫昔芬对子宫内膜产生影响的可能机制。
