Vance J C, Chant D C, Tudehope D I, Gray P H, Hayes A J
Department of Paediatrics and Child Health, Mater Children's Hospital, South Brisbane, Australia.
J Paediatr Child Health. 1997 Dec;33(6):504-8. doi: 10.1111/j.1440-1754.1997.tb01659.x.
To describe the physical growth patterns of infants born to narcotic dependent mothers (INDM) over a 12 months period and, if possible, to relate the growth to drug taking patterns during pregnancy.
The growth of a cohort of 43 INDM was measured during the first 12 months of life. Weight and length measurements were compared with percentile charts and converted to Z scores. Questionnaire data about drug taking practices, demographic variables and the neonatal period (including withdrawal scores) were obtained.
Twenty-four (55.8%) of INDM had evidence of neonatal drug withdrawal requiring treatment with phenobarbitone. At birth, Z scores for weight and length indicated relative intrauterine growth retardation. By 12 months, there had been some catch up growth, but Z scores for weight and length were still below zero. Persistent weight retardation at 12 months was correlated with methadone dosage during pregnancy, but not the need for phenobarbitone therapy.
The growth patterns of INDM in the first 12 months of life indicated that at birth there was evidence of intrauterine growth retardation, but by 12 months the growth was little different from the rest of the community. There appears to be some influence of narcotic agents taken while pregnant on subsequent growth of INDM.
描述麻醉品依赖母亲所生婴儿（INDM）在12个月期间的身体生长模式，并在可能的情况下，将生长情况与孕期吸毒模式联系起来。
对一组43名INDM婴儿在出生后的前12个月进行生长测量。将体重和身长测量值与百分位图表进行比较，并转换为Z分数。获取有关吸毒行为、人口统计学变量和新生儿期（包括戒断分数）的问卷数据。
24名（55.8%）INDM有新生儿药物戒断的证据，需要用苯巴比妥治疗。出生时，体重和身长的Z分数表明存在相对宫内生长迟缓。到12个月时，有一些追赶性生长，但体重和身长的Z分数仍低于零。12个月时持续的体重迟缓与孕期美沙酮剂量相关，但与是否需要苯巴比妥治疗无关。
INDM在出生后前12个月的生长模式表明，出生时有宫内生长迟缓的证据，但到12个月时，其生长与社区其他婴儿几乎没有差异。孕期服用麻醉剂似乎对INDM的后续生长有一定影响。
