血清胰岛素样生长因子I和II不受非器质性发育不良儿童营养不良的影响。
Serum insulin-like growth factors I and II are not affected by undernutrition in children with nonorganic failure to thrive.
作者信息
Phillip M, Hershkovitz E, Rosenblum H, Savion I, Segev Y, Levy J, Frazer D
机构信息
Pediatric Diagnostic and Therapeutic Center, Soroka Medical Center and Ben Gurion University of the Negev, Beer-Sheva, Israel.
出版信息
Horm Res. 1998;49(2):76-9. doi: 10.1159/000023130.
The aim of our study was to determine the serum levels of IGF-I, IGF-II, and their binding proteins IGFBP-1 and IGFBP-3 in young children 3 months to 2 years of age with nonorganic failure to thrive (NOFTT). 29 children with NOFTT and 32 normal controls were recruited and studied for auxologic and hormonal parameters. The NOFTT group had significantly higher serum concentrations of IGFBP-1 than the control group: 57.7+/-18 vs. 48+/-19 microg/l (p < 0.05). IGF-I and IGF-II serum levels were highly correlated to serum IGFBP-3 but there were no differences in the serum IGF-I, IGF-II and IGFBP-3 levels between the groups. We conclude that IGF-I, IGF-II, and IGFBP-3 are not useful for the evaluation of nutritional status in children, under the age of 2 years, with NOFTT.
我们研究的目的是测定3个月至2岁非器质性生长发育迟缓（NOFTT）幼儿的血清胰岛素样生长因子-I（IGF-I）、胰岛素样生长因子-II（IGF-II）及其结合蛋白胰岛素样生长因子结合蛋白-1（IGFBP-1）和胰岛素样生长因子结合蛋白-3（IGFBP-3）的水平。招募了29例NOFTT患儿和32例正常对照儿童，对其进行体格和激素参数研究。NOFTT组血清IGFBP-1浓度显著高于对照组：57.7±18 vs. 48±19 μg/l（p<0.05）。血清IGF-I和IGF-II水平与血清IGFBP-3高度相关，但两组间血清IGF-I、IGF-II和IGFBP-3水平无差异。我们得出结论，IGF-I、IGF-II和IGFBP-3对评估2岁以下NOFTT儿童的营养状况无用。
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