Vigil-De Gracia P, García-Cáceres E
Department of Obstetrics and Gynecology, Complejo Hospitalario Metropolitano de la Caja de Seguro Social, Panamá City, Panamá.
Int J Gynaecol Obstet. 1997 Dec;59(3):217-21. doi: 10.1016/s0020-7292(97)00214-2.
To determine if the routine initiation of dexamethasone in patients with post-partum HELLP syndrome produces therapeutic benefits.
The puerperal courses of 17 mothers who initially received dexamethasone after delivery were compared to 17 other mothers with HELLP syndrome who received no corticosteroids during the puerperium course. Treated patients immediately received 10 mg of dexamethasone post-partum (intravenously) followed 12 h later by 10 mg and 10 mg at 24 h post-partum, to a total of 30 mg.
The steroid treated group had significant changes over time in platelet count. Relative to the control group the platelet count increased significantly by 30 h post-partum (P < 0.01). The blood pressure, urinary output, lactic dehydrogenase, aspartato aminotransferase and alanine aminotransferase values were not significantly different between the dexamethasone and control group at any time by 72 h post-partum.
Parturients with HELLP syndrome who received a short course of post-partum dexamethasone therapy had an accelerated recovery from their platelet count, but not from their liver enzymes and blood pressure.
确定产后HELLP综合征患者常规使用地塞米松是否产生治疗益处。
将17例产后最初接受地塞米松治疗的母亲的产褥期病程与另外17例在产褥期未接受皮质类固醇治疗的HELLP综合征母亲进行比较。治疗组患者产后立即静脉注射10mg地塞米松，12小时后注射10mg，产后24小时再注射10mg，总量为30mg。
类固醇治疗组血小板计数随时间有显著变化。与对照组相比，产后30小时血小板计数显著增加（P<0.01）。产后72小时内的任何时间，地塞米松组和对照组的血压、尿量、乳酸脱氢酶、天冬氨酸转氨酶和丙氨酸转氨酶值均无显著差异。
接受短期产后地塞米松治疗的HELLP综合征产妇血小板计数恢复加快，但肝酶和血压恢复未加快。
