Matar P, Rozados V R, Roggero E A, Bonfil R D, Scharovsky O G
Instituto de Genética Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Argentina.
Tumour Biol. 1998;19(2):69-76. doi: 10.1159/000029977.
The aim of this paper was to identify the mechanism/s responsible of the antimetastatic effect of a single low dose of cyclophosphamide (Cy), previously demonstrated by us in the rat lymphoma LTACB. No direct cytotoxic antimetastatic activity of Cy could be proved. In vitro treatment of L-TACB cells with mafosfamide did not alter their invasiveness or their motility. The adoptive transfer of splenocytes from Cy-treated tumor-bearing rats, together with L-TACB cells inhibited their metastatic growth. The single low dose Cy treatment of T-immunodeficient nude mice did not show the antimetastatic effect on L-TACB observed in immunocompetent mice. An inhibition of the metastatic ability due to immunomodulation by Cy is proposed.
本文的目的是确定单次低剂量环磷酰胺（Cy）抗转移作用的机制，此前我们已在大鼠淋巴瘤LTACB中证实了该作用。无法证明Cy具有直接的细胞毒性抗转移活性。用马磷酰胺对L-TACB细胞进行体外处理，并未改变其侵袭性或运动性。将经Cy处理的荷瘤大鼠的脾细胞与L-TACB细胞进行过继性转移，可抑制其转移生长。对T细胞免疫缺陷的裸鼠进行单次低剂量Cy处理，未显示出在免疫活性小鼠中观察到的对L-TACB的抗转移作用。有人提出，Cy通过免疫调节抑制转移能力。
