Alonso-Llamazares J, Ahmed I
Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.
J Am Acad Dermatol. 1998 Feb;38(2 Pt 2):322-4. doi: 10.1016/s0190-9622(98)70574-2.
We describe a 45-year-old white man in whom distinctive clinical and histologic features of localized scleroderma developed at sites of injection of vitamin K1 (phytonadione). A direct immunofluorescence test demonstrated prominent linear deposition of IgA along the basement membrane zone. No circulating antibasement membrane zone IgA antibodies were identified on indirect immunofluorescence testing. We believe that the unusual immunofluorescence finding in our patient is nonspecific and represents an epiphenomenon caused by cutaneous injury.
我们描述了一名45岁的白人男性，在其接受维生素K1（叶绿醌）注射的部位出现了局限性硬皮病独特的临床和组织学特征。直接免疫荧光检测显示IgA沿基底膜带呈显著线性沉积。间接免疫荧光检测未发现循环抗基底膜带IgA抗体。我们认为，该患者不寻常的免疫荧光发现是非特异性的，代表了由皮肤损伤引起的一种附带现象。
