Operti M G, Vincent M F, Brucher J M, van den Berghe G
Laboratory of Physiological Chemistry, International Institute of Cellular and Molecular Pathology, UCL 75.39, Brussels, Belgium.
Muscle Nerve. 1998 Mar;21(3):401-3. doi: 10.1002/(sici)1097-4598(199803)21:3<401::aid-mus16>3.0.co;2-1.
The activities of adenylosuccinate synthetase, adenylosuccinate lyase, and adenosine monophosphate deaminase were measured in muscle from patients suffering from fatigue and cramps following exercise. Results denote the existence of secondary deficiencies of adenylosuccinate synthetase and/or adenylosuccinate lyase in subjects with congenital or acquired myopathies. They also suggest that searches are warranted for primary deficiencies of adenylosuccinate synthetase as a cause of exercise intolerance.
对运动后出现疲劳和痉挛的患者的肌肉中腺苷酸琥珀酸合成酶、腺苷酸琥珀酸裂解酶和单磷酸腺苷脱氨酶的活性进行了测定。结果表明，先天性或后天性肌病患者存在腺苷酸琥珀酸合成酶和/或腺苷酸琥珀酸裂解酶的继发性缺乏。研究结果还表明，有必要对作为运动不耐受原因的腺苷酸琥珀酸合成酶原发性缺乏进行研究。
