Jensen-Urstad M, Jensen-Urstad K, Ericson M, Johansson J
Department of Cardiology, Huddinge University Hospital, Sweden.
J Intern Med. 1998 Jan;243(1):33-40.
To investigate if, in a healthy randomly-selected population of 35-year-old men and women, there already is a relation between decreased heart rate variability and conventional risk factors for cardiovascular disease.
Analysis of heart rate variability (HRV) has been used for estimating tonic autonomic activity. HRV is reduced in patients with various cardiovascular diseases. If a decreased HRV is a late phenomenon in the progression of cardiovascular disease, or if it parallels or even precedes manifest disease is unknown.
Spectral analysis of HRV was made from 24-hour ambulatory electrocardiograms in a randomised population of healthy 35-year-old men (n = 63) and women (n = 70). The different spectral indices of HRV were analysed against gender, leucocyte count (previously described as an independent risk factor for cardiovascular disease), blood lipoproteins, smoking, heredity, body mass index (BMI) and systolic blood pressure.
A research centre of general medicine and a university hospital.
Mean heart rate was lower, total power (TP), very low frequency power (VLF) and low frequency power (LF) were higher in men than in women. In women TP, VLF and LF were negatively correlated to BMI, smoking, triglycerides and positively correlated to HDL cholesterol. TP and VLF were also negatively correlated to risk factor score. High frequency power (HF), a marker of parasympathetic activity, was positively related to HDL cholesterol. In men, at daytime, TP, VLF, LF and HF were negatively correlated to leucocyte count. TP, VLF and LF were also negatively correlated to triglycerides and VLF also to risk factor score.
There are correlations between HRV and known risk factors for cardiovascular disease already in a healthy 35-year-old population. A novel observation is the relationship in men between leucocyte count and heart rate variability.
调查在随机选取的35岁健康男女群体中，心率变异性降低与心血管疾病传统危险因素之间是否已经存在关联。
心率变异性（HRV）分析已用于评估自主性紧张活动。各种心血管疾病患者的HRV降低。HRV降低是心血管疾病进展中的晚期现象，还是与显性疾病平行甚至先于显性疾病出现尚不清楚。
对随机选取的63名35岁健康男性和70名35岁健康女性进行24小时动态心电图HRV频谱分析。针对性别、白细胞计数（先前被描述为心血管疾病的独立危险因素）、血脂蛋白、吸烟、遗传、体重指数（BMI）和收缩压，分析HRV的不同频谱指标。
一家普通医学研究中心和一家大学医院。
男性的平均心率较低，总功率（TP）、极低频功率（VLF）和低频功率（LF）高于女性。在女性中，TP、VLF和LF与BMI、吸烟、甘油三酯呈负相关，与高密度脂蛋白胆固醇呈正相关。TP和VLF也与危险因素评分呈负相关。高频功率（HF）是副交感神经活动的标志物，与高密度脂蛋白胆固醇呈正相关。在男性中，白天TP、VLF、LF和HF与白细胞计数呈负相关。TP、VLF和LF也与甘油三酯呈负相关，VLF还与危险因素评分呈负相关。
在35岁的健康人群中，HRV与已知的心血管疾病危险因素之间存在相关性。一个新的发现是男性白细胞计数与心率变异性之间的关系。
