Koskinen T, Kähönen M, Jula A, Mattsson N, Laitinen T, Keltikangas-Järvinen L, Viikari J, Välimäki I, Rönnemaa T, Raitakari O T
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland.
Diabet Med. 2009 Apr;26(4):354-61. doi: 10.1111/j.1464-5491.2009.02686.x.
Heart rate variability (HRV) can be used to estimate autonomic nervous control of the cardiovascular system. In middle-aged subjects, the metabolic syndrome (MetS) is associated with lower HRV. We hypothesized that alterations in autonomic balance are already present in young adults with the MetS, and analysed the association of short-term HRV with the MetS (using the National Cholesterol Education Program definition), in 1889 subjects aged 24-39 years.
Short-term (3 min) HRV analysis included high-frequency (HF), low-frequency (LF) and total (TP) spectral components of HRV and LF/HF ratio.
The presence of the MetS was associated with lower HF, LF and TP in men and women, and with higher LF/HF ratio in women. In men, waist circumference was the strongest individual MetS component that associated with HRV. After adjustments for age and heart rate, MetS was associated with lower HF and higher LF/HF ratio in women, but only with a lower TP in men (all P < 0.05).
MetS is associated with lower HRV in young adults. The individual components of MetS are differentially associated with HRV in men and in women. Our results are consistent with lower vagal activity and a possible increase in sympathetic predominance in women with the MetS. This sex difference in vagal activity and sympathovagal balance may partly explain the greater increase in cardiovascular risk associated with MetS in women than in men.
心率变异性（HRV）可用于评估心血管系统的自主神经控制。在中年受试者中，代谢综合征（MetS）与较低的HRV相关。我们推测，患有MetS的年轻成年人已经存在自主神经平衡的改变，并分析了1889名年龄在24 - 39岁的受试者中短期HRV与MetS（使用美国国家胆固醇教育计划的定义）之间的关联。
短期（3分钟）HRV分析包括HRV的高频（HF）、低频（LF）和总功率（TP）频谱成分以及LF/HF比值。
MetS的存在与男性和女性较低的HF、LF和TP相关，与女性较高的LF/HF比值相关。在男性中，腰围是与HRV相关的最强的个体MetS组成部分。在调整年龄和心率后，MetS与女性较低的HF和较高的LF/HF比值相关，但仅与男性较低的TP相关（所有P < 0.05）。
MetS与年轻成年人较低的HRV相关。MetS的个体组成部分在男性和女性中与HRV的关联有所不同。我们的结果与患有MetS的女性迷走神经活动降低和交感神经优势可能增加一致。迷走神经活动和交感 - 迷走神经平衡的这种性别差异可能部分解释了与MetS相关的女性心血管风险增加幅度大于男性的原因。
