Crowley J J, Shapiro L M
Regional Cardiac Unit, Papworth Hospital, Cambridge, United Kingdom.
J Am Soc Echocardiogr. 1998 Jan;11(1):1-9. doi: 10.1016/s0894-7317(98)70113-0.
This study was performed (1) to test whether transthoracic echocardiography may detect coronary flow velocity in the left anterior descending coronary artery distal to stenoses; and (2) to noninvasively assess coronary artery hemodynamics distal to coronary artery stenoses. High-frequency transthoracic echocardiography was used to assess blood velocity patterns in the distal segment of the left anterior descending coronary artery of 128 consecutive patients (mean age, 58 +/- 9 years; 97 men and 31 women) who underwent cardiac catheterization for investigation of angina. Biphasic, diastolic predominant Doppler velocity patterns were obtained in 67 patients (52%). There was no significant difference in any measurements of systolic blood velocity between patients with unobstructed (less than 30% stenosis) left anterior descending coronary artery, moderate stenosis (30% to 70% obstruction), or severe stenosis (more than 70% obstruction). Patients with severe stenosis demonstrated a reduction in the diastolic component of blood flow velocity in the distal left anterior descending coronary artery compared with patients in the other two groups. This technique may be useful for the noninvasive assessment of the significance of stenotic left anterior descending coronary artery disease or the outcome of interventional procedures.
（1）测试经胸超声心动图能否检测狭窄远端左前降支冠状动脉的血流速度；（2）无创评估冠状动脉狭窄远端的冠状动脉血流动力学。对128例因心绞痛接受心脏导管检查的连续患者（平均年龄58±9岁；97例男性，31例女性），使用高频经胸超声心动图评估左前降支冠状动脉远端节段的血流速度模式。67例患者（52%）获得了双相、以舒张期为主的多普勒速度模式。左前降支冠状动脉无梗阻（狭窄小于30%）、中度狭窄（30%至70%梗阻）或重度狭窄（超过70%梗阻）的患者，其收缩期血流速度的任何测量值均无显著差异。与其他两组患者相比，重度狭窄患者左前降支冠状动脉远端血流速度的舒张期成分降低。该技术可能有助于无创评估左前降支冠状动脉狭窄性疾病的严重程度或介入治疗的效果。
