Mörk H, al-Taie O, Klinge O, Scheurlen M
Medizinische Poliklinik, Universität Würzburg.
Z Gastroenterol. 1997 Dec;35(12):1087-91.
Drug-induced cholestasis can rarely persist for a considerable time period even after withdrawal of the drug. We report the case of a 55-year-old man with progressive jaundice after oral therapy with 17-alpha-methyltestosterone. Under empiric therapy with ursodeoxycholic acid the condition resolved completely. According to this observation, we suggest a therapeutic trial with ursodeoxycholic acid in cases of prolonged androgen-induced cholestasis.
药物性胆汁淤积即使在停药后也很少会持续相当长的一段时间。我们报告一例55岁男性，在口服17-α-甲基睾酮治疗后出现进行性黄疸。在熊去氧胆酸经验性治疗下，病情完全缓解。根据这一观察结果，我们建议在雄激素诱导的长期胆汁淤积病例中进行熊去氧胆酸治疗试验。
