Duffield D A, Goldie P L
Department of Biology, Portland State University, OR 97201, USA.
J Hered. 1998 Jan-Feb;89(1):104-6. doi: 10.1093/jhered/89.1.104.
In a study of 2,786 tobiano and non-tobiano horses involved in paint horse breeding programs throughout the United States, the inheritance of the tobiano color pattern gene was tracked in pedigrees using the tightly linked polymorphic albumin gene. The dominant tobiano allele (T(o)), which produces the tobiano spotting pattern in horses, was in coupling with both AIA and AIB alleles at the albumin locus. The frequency of the T(o):AIA linkage phase among all the homozygous tobiano horses in this study including offspring and parents (N = 127), was 0.08. The T(o):AIB linkage phase was the most frequent (0.92). Linkage disequilibrium exists between the tobiano and albumin loci. The linkage disequilibrium parameter (D) was calculated as D = 0.056 at 79% of maximum linkage disequilibrium.
在一项对美国各地参与花马繁育计划的2786匹托比亚诺马和非托比亚诺马的研究中，利用紧密连锁的多态性白蛋白基因在谱系中追踪托比亚诺毛色模式基因的遗传情况。显性托比亚诺等位基因（T(o)）在马中产生托比亚诺斑点模式，它与白蛋白位点的AIA和AIB等位基因处于耦合状态。在本研究中包括后代和父母的所有纯合托比亚诺马（N = 127）中，T(o):AIA连锁相的频率为0.08。T(o):AIB连锁相最为常见（0.92）。托比亚诺和白蛋白位点之间存在连锁不平衡。连锁不平衡参数（D）在最大连锁不平衡的79%时计算为D = 0.056。
