An immunological approach to prion diseases.

Ovine scrapie and bovine spongiform encephalopathy are genetic diseases, presenting probably autoimmunity transmissible by the oral route. The absence of immune response in prion diseases indicates a tolerant state for PrP(C) and PrP(SC). The tolerant state against these diseases should be overcome before immunizing animals. We suggest that an early diagnosis may be possible using polyclonal and monoclonal antibodies specific for either ovine or bovine PrP(SC). Such reagents could be obtained by immunizing corresponding animals with peptides from beta sheet molecules bound to a linker or with the complete molecule (27-30 kDa).