Miura N, Terai M, Meng Y G, Sato T, Niimi H
Department of Paediatrics, School of Medicine, Chiba University, Japan.
Br J Haematol. 1998 Feb;100(2):387-8. doi: 10.1046/j.1365-2141.1998.00584.x.
Kawasaki disease (KD) is an acute febrile vasculitic syndrome with thrombocytosis occurring in childhood. Transient thrombocytosis of KD is sometimes the cause of complications such as coronary aneurysmal thrombosis and myocardial infarction. We have analysed blood TPO levels in KD and found that 26/31 acute-phase KD patients had detectable blood TPO levels (mean 173 pg/ml; range 89-294 pg/ml), which decreased immediately with the elevation of platelet counts in 5/12 patients studied. Elevated serum level of TPO may have an important role for this ill-defined disease.
川崎病（KD）是一种发生于儿童期的急性发热性血管炎综合征，伴有血小板增多。川崎病的短暂性血小板增多有时是冠状动脉瘤血栓形成和心肌梗死等并发症的原因。我们分析了川崎病患者的血液血小板生成素（TPO）水平，发现31例急性期川崎病患者中有26例血液TPO水平可检测到（平均173 pg/ml；范围89 - 294 pg/ml），在12例研究患者中有5例患者的TPO水平随着血小板计数升高而立即下降。TPO血清水平升高可能在这种病因不明的疾病中起重要作用。
