Tanaka M, Murakami S, Igarashi T, Abe T, Suzuki K, Sekita N, Shimazaki J
Department of Urology, Asahi General Hospital.
Hinyokika Kiyo. 1997 Dec;43(12):855-60.
Thirty seven patients complaining of voiding disturbance who showed gray zone total prostate-specific antigen (t-PSA) level (upper limit of normal approximately 10 ng/ml) but did not reveal apparent cancerous findings in the prostate were examined for free PSA (f-PSA) and prostate volume. According to histological diagnosis, 9 were cancer cases and the other 28 were non-cancer cases. The free/total (F/T) ratio was 0.10 and 0.16 in the cancer and non-cancer groups, respectively (t-PSA; DPC kit, p = 0.03). The t-PSA (DPC and Dinabott kits), f-PSA and PSA density alone did not distinguish these two groups. For diagnosis of cancer, the ratio seemed to be F/T, the most reliable followed by PSA density and t-PSA. When using a 13% F/T, the sensitivity and specificity for cancer detection were 88.9 and 70.8%, respectively. t-PSA measured with the Dinabott kit, showed a similar tendency except that the F/T ratio showed a slight variation. Prostate volume and patient age influenced the F/T slightly, but these factors may not impair the usefulness of F/T.
37例主诉排尿障碍的患者，其总前列腺特异性抗原（t-PSA）水平处于灰色区间（正常上限约为10 ng/ml），且前列腺未发现明显癌变迹象，对其进行了游离PSA（f-PSA）和前列腺体积检测。根据组织学诊断，9例为癌症病例，其余28例为非癌症病例。癌症组和非癌症组的游离/总（F/T）比值分别为0.10和0.16（t-PSA；DPC试剂盒，p = 0.03）。单独的t-PSA（DPC和Dinabott试剂盒）、f-PSA和PSA密度无法区分这两组。对于癌症诊断，F/T比值似乎是最可靠的，其次是PSA密度和t-PSA。当F/T比值为13%时，癌症检测的灵敏度和特异性分别为88.9%和70.8%。用Dinabott试剂盒测量的t-PSA显示出类似趋势，只是F/T比值略有变化。前列腺体积和患者年龄对F/T有轻微影响，但这些因素可能不会损害F/T的实用性。
