Durand M C, Goulon-Goeau C, Gajdos P
Service central d'explorations fonctionnelles, hôpital Raymond-Poincaré, Garches, France.
Neurophysiol Clin. 1997 Dec;27(6):471-82. doi: 10.1016/s0987-7053(97)82019-9.
Ninety five patients with global muscular weakness or purely extraocular weakness were included in a retrospective study. Electrical micro stimulation and single fiber electromyography were performed in all, for neuromuscular jitter evaluation in myasthenia gravis diagnosis. In our study, increased jitter was more often present (70% of generalised myasthenia gravis and 57% of ocular myasthenia gravis) than decrement after repetitive nerve stimulations (58% of generalised myasthenia gravis and 14% of ocular myasthenia gravis). Increased jitter was also found in non-myasthenic patients. With the aim of a better sensitivity and specificity of the electrophysiological diagnosis for myasthenia gravis a protocol is described.
一项回顾性研究纳入了95例患有全身性肌无力或单纯眼外肌无力的患者。对所有患者进行了电微刺激和单纤维肌电图检查，以评估重症肌无力诊断中的神经肌肉抖动。在我们的研究中，与重复神经刺激后出现波幅递减的情况（全身性重症肌无力患者中占58%，眼肌型重症肌无力患者中占14%）相比，抖动增加更为常见（全身性重症肌无力患者中占70%，眼肌型重症肌无力患者中占57%）。在非重症肌无力患者中也发现了抖动增加的情况。为了提高重症肌无力电生理诊断的敏感性和特异性，本文描述了一种方案。
