Kuwayama H, Fukuyo M
Department of Gastroenterology & Hepatology, University Hospital at Koshigaya, Dokkyo University School of Medicine, Japan.
Nihon Geka Gakkai Zasshi. 1997 Nov;98(11):932-5.
It is now widely accepted that peptic ulcer disease (PUD) is a result of chronic infection of Helicobacter pylori (H. pylori). Thus, treatment of PUD should be aimed toward eradication of H. pylori with antibiotics. One the other hand, recent study from England suggested that eradication of H. pylori may provoke development of reflux esophagitis in duodenal ulcer patients. Despite duodenall ulcer patients with concomitant esophagitis is a specific type of esophagitis, it is important to recognize the development of reflux esophagitis after cure of H. pylori infection. Whether the development of reflux esophagitis is occurred in other H. pylori-related disease such as gastric ulcer remains to be studied.
现在人们普遍认为，消化性溃疡病（PUD）是幽门螺杆菌（H. pylori）慢性感染的结果。因此，PUD的治疗应旨在使用抗生素根除幽门螺杆菌。另一方面，英国最近的研究表明，根除幽门螺杆菌可能会引发十二指肠溃疡患者反流性食管炎的发展。尽管伴有食管炎的十二指肠溃疡患者是一种特殊类型的食管炎，但认识到幽门螺杆菌感染治愈后反流性食管炎的发展很重要。反流性食管炎是否会在其他幽门螺杆菌相关疾病如胃溃疡中发生仍有待研究。
