Fletcher S, Wright M, Wilkinson A, Farr M, Sellars L
Renal Unit, Hull Royal Infirmary, UK.
Int J Clin Pract. 1997 Jul-Aug;51(5):324-5.
Patients with severe peripheral vascular disease may suffer considerable pain which can be difficult to control with conventional analgesics. We sought to assess the analgesic effect of transdermal nitrate patches in such patients. A prospective trial was performed in 15 patients with ischaemic rest pain due to atherosclerotic peripheral vascular disease. Pain control and oral analgesic requirement were assessed. Fourteen of the 15 had a good or moderate response to the nitrate patches with a subsequent reduction in oral analgesic requirement. The patients with primarily small vessel disease had the greatest improvement in pain control. We conclude that topical nitrates may be used to provide rapid and safe analgesia for patients with ischaemic rest pain.
患有严重外周血管疾病的患者可能会遭受剧烈疼痛，而传统镇痛药可能难以控制这种疼痛。我们试图评估透皮硝酸酯贴片对此类患者的镇痛效果。对15例因动脉粥样硬化性外周血管疾病导致静息痛的患者进行了一项前瞻性试验。评估了疼痛控制情况和口服镇痛药的需求。15例患者中有14例对硝酸酯贴片有良好或中度反应，随后口服镇痛药的需求减少。主要患有小血管疾病的患者在疼痛控制方面改善最大。我们得出结论，局部用硝酸盐可为患有静息痛的患者提供快速、安全的镇痛作用。
