Chen Y, Rennie D C, Lockinger L A, Dosman J A
Department of Epidemiology and Community Medicine, University of Ottawa, Ontario, Canada.
Am J Med Genet. 1998 Feb 17;75(5):485-91.
We report the results of segregation analyses for wheeze before and after a history of respiratory allergy was taken into consideration. The analyses were based on data from 309 nuclear families with 1,053 individuals living in the town of Humboldt, Saskatchewan in 1993, and were performed by using the REGD program of the SAGE package. For adults, information on wheeze and history of respiratory allergy was provided by themselves, and for children, by their parents. Segregation analyses were first conducted before adjustment for history of respiratory allergy. Other covariates were adjusted including sex, current smoking, household exposure to tobacco smoke, and type of house. A single locus model with residual familial effects fit the data well, but none of the Mendelian models (recessive, dominant, and codominant) could be distinguished. The no-parent-offspring-transmission hypothesis was rejected. However, when the variable of respiratory allergy was included in the models as a covariate, both Mendelian and environmental hypotheses were rejected. The Mendelian model had a relatively lower value of Akaike's Information Criterion than did the environmental model (1095.56 versus 1111.24). The data suggest that a single locus gene explains a portion of wheeze that is related to respiratory allergy, and that common environmental factors and/or polygenes also account for a certain familial aggregation of wheeze.
我们报告了在考虑呼吸道过敏史前后对喘息进行分离分析的结果。这些分析基于1993年居住在萨斯喀彻温省洪堡镇的309个核心家庭中1053人的数据，并使用SAGE软件包中的REGD程序进行。对于成年人，喘息和呼吸道过敏史的信息由他们自己提供，对于儿童，则由他们的父母提供。分离分析首先在未调整呼吸道过敏史的情况下进行。还对其他协变量进行了调整，包括性别、当前吸烟情况、家庭接触烟草烟雾情况和房屋类型。一个具有残余家族效应的单基因座模型与数据拟合良好，但无法区分任何孟德尔模型（隐性、显性和共显性）。亲子传递假说被拒绝。然而，当将呼吸道过敏变量作为协变量纳入模型时，孟德尔假说和环境假说均被拒绝。孟德尔模型的赤池信息准则值比环境模型相对较低（1095.56对1111.24）。数据表明，一个单基因座基因解释了与呼吸道过敏相关的一部分喘息，并且常见环境因素和/或多基因也导致了喘息的一定家族聚集性。
