Tsutsui K, Hasegawa M, Takata M, Takehara K
Department of Dermatology, Kanazawa University School of Medicine, Japan.
J Rheumatol. 1998 Feb;25(2):326-8.
To assess the role of granulocyte elastase in the development of thromboembolic vasculopathy in patients with Behçet's disease.
Plasma granulocyte elastase-alpha1-proteinase inhibitor (E-PI) complex levels were measured by ELISA in 11 healthy subjects and 19 patients with Behçet's disease (BD). Eight of 19 patients showed deep vein thrombosis on (99m)technetium-macro-agglutinate albumin venography. Hemostatic variables were measured at the same time.
The mean plasma E-PI complex level was significantly higher in the 8 patients with than in the 11 patients without deep vein thrombosis (242 +/- 73 vs 165 +/- 97 ng/ml; p = 0.033). The mean plasma E-PI complex level in the 11 patients without deep vein thrombosis was significantly higher than in controls (165 +/- 97 vs 96 +/- 40 ng/ml; p = 0.038). Plasma E-PI complex levels correlated with the serum plasmin-alpha2-plasmin inhibitor complex levels (r = 0.621, p = 0.0084).
Plasma E-PI complex levels appear to be a useful marker of thromboembolic vasculopathy in BD.
评估粒细胞弹性蛋白酶在白塞病患者血栓栓塞性血管病发展中的作用。
采用酶联免疫吸附测定法（ELISA）检测11名健康受试者和19名白塞病（BD）患者血浆中粒细胞弹性蛋白酶-α1-蛋白酶抑制剂（E-PI）复合物水平。19名患者中有8名在锝-大颗粒聚合人血清白蛋白静脉造影中显示深静脉血栓形成。同时检测止血变量。
8例有深静脉血栓形成的患者血浆E-PI复合物平均水平显著高于11例无深静脉血栓形成的患者（242±73对165±97 ng/ml；p = 0.033）。11例无深静脉血栓形成的患者血浆E-PI复合物平均水平显著高于对照组（165±97对96±40 ng/ml；p = 0.038）。血浆E-PI复合物水平与血清纤溶酶-α2-纤溶酶抑制剂复合物水平相关（r = 0.621，p = 0.0084）。
血浆E-PI复合物水平似乎是白塞病血栓栓塞性血管病的一个有用标志物。
