骨化三醇在调节角化不全皮肤特征过程中活性的实验性初步研究。

An experimental pilot study of tacalcitol activities during modulation of parakeratotic skin features.

作者信息

Tucci M G, Ricotti G, Giardino R, Carraro S, Mattei G, Cataldi I, Lucarini G, Solmi R, Tosi L, Biagini G

机构信息

Dipartimento Ricerche, I.N.R.C.A., Ancona, Italy.

出版信息

Cell Mol Biol (Noisy-le-grand). 1997 Dec;43(8):1213-20.

PMID:9489947

Abstract

Establishing guidelines and experimental models preclinical and clinical evaluations of new agents for treatment, and/or prevention of human diseases has become a task of crucial importance. Psoriasis is such one disease holding great interest for dermatology owing to its high rate of incidence and complexity of treatment. However the absence of psoriatic lesions in animals and the inability to induce them, calls for experimental techniques both in vitro and in vivo. The purpose of this study was to evaluate experimentally the effects of tacalcitol on cell proliferation and differentiation process. Thereafter a human pilot study on psoriatic patients has been developed.

摘要

建立用于新治疗和/或预防人类疾病药物的临床前和临床评估的指南及实验模型已成为一项至关重要的任务。银屑病是一种因发病率高且治疗复杂而备受皮肤科关注的疾病。然而，动物身上不存在银屑病病变且无法诱导其产生，这就需要体外和体内实验技术。本研究的目的是通过实验评估他卡西醇对细胞增殖和分化过程的影响。此后，针对银屑病患者开展了一项人体初步研究。