Danilewicz M, Wagrowska-Danilewicz M
Department of Pathology, Medical University of Lódź, Poland.
Gen Diagn Pathol. 1997 Dec;143(4):225-30.
15 renal biopsy specimens from patients with mesangial proliferative glomerulopathy (MPGN), 15 from patients with IgA nephropathy (IgAN), and 15 from patients with mesangiocapillary glomerulopathy type I (MCGN-I), for whom both light and electron microscopy as well as immunofluorescence microscopy and full clinical data were available, were examined and compared with 15 normal controls. Morphometric investigations were performed by means of a computer image analysis system to evaluate quantitatively the glomerular deposition of PAS positive material in these glomerulopathies, as well as to assay whether this parameter could correlate with the renal function. The morphometric study demonstrated that the mean values of glomerular deposition of PAS positive material (% of total glomerular area) were similar in MPGN, IgAN, and MCGN-I. Although correlations between glomerular deposition of PAS positive material and serum creatinine tended to be positive in MPGN, IgAN and MCGN-I, they were weak and not significant. Thus, the present study could not confirm earlier suggestions concerning a significant correlation between these parameters.
选取了15例系膜增生性肾小球病（MPGN）患者、15例IgA肾病（IgAN）患者以及15例I型系膜毛细血管性肾小球病（MCGN-I）患者的肾活检标本，这些患者均有光镜、电镜、免疫荧光显微镜检查结果及完整的临床资料，并与15例正常对照进行比较。采用计算机图像分析系统进行形态计量学研究，以定量评估这些肾小球疾病中PAS阳性物质的肾小球沉积情况，并分析该参数是否与肾功能相关。形态计量学研究表明，MPGN、IgAN和MCGN-I中PAS阳性物质的肾小球沉积平均值（占肾小球总面积的百分比）相似。虽然在MPGN、IgAN和MCGN-I中，PAS阳性物质的肾小球沉积与血清肌酐之间的相关性倾向于呈阳性，但这种相关性较弱且无统计学意义。因此，本研究无法证实之前有关这些参数之间存在显著相关性的观点。
