Linde B
Acta Physiol Scand. 1976 Jun;97(2):166-74. doi: 10.1111/j.1748-1716.1976.tb10249.x.
Net transvascular movement of fluid has been studied in the isolated, autoperfused subcutaneous adipose tissue of the dog, during and after sympathetic nerve stimulation (1-15 Hz) and during infusion of 50% glucose i.a. Net fluid movement was calculated as the difference between change in tissue volume and change in blood volume. Tissue volume was measured by plethysmography and blood volume by external monitoring of circulating 131I-albumin. No net fluid movement of statistical significance was found during or after nerve stimulation except during the first minute of stimulation at 15 Hz when a small net absorption (p less than 0.05) was obtained. In contrast, infusion of glucose at 25-75 mOsm/kg H2O produced a dose-dependent net absorption lasting several minutes, amounting maximally to 0.30 ml x min-1 x 100 g-1. The absence of prolonged net absorption in subcutaneous adipose tissue during nerve stimulation as well as the absence of net filtration after stimulation may be explained by an essentially unaltered mean hydrostatic capillary pressure. The results indicate that adipose tissue does not contribute to the fluid homeostasis of the body via sympathetic resetting of the pre-postcapillary resistance ratio. Thus, mobilisation of fluid from the interstitial space in adipose tissue into the blood does not seem to occur by nerve activity.
在犬的离体自灌注皮下脂肪组织中，研究了交感神经刺激（1 - 15Hz）期间及之后以及经动脉注射50%葡萄糖期间的液体跨血管净移动。净液体移动量通过组织体积变化与血容量变化之差来计算。组织体积通过体积描记法测量，血容量通过循环的131I - 白蛋白的外部监测来测量。除了在15Hz刺激的第一分钟出现小的净吸收（p小于0.05）外，在神经刺激期间及之后未发现具有统计学意义的净液体移动。相比之下，以25 - 75mOsm/kg H2O的浓度注射葡萄糖会产生持续数分钟的剂量依赖性净吸收，最大量达到0.30ml·min-1·100g-1。神经刺激期间皮下脂肪组织缺乏长时间的净吸收以及刺激后缺乏净滤过，可能是由于平均毛细血管静水压基本未改变所致。结果表明，脂肪组织不会通过交感神经调节毛细血管前 - 后阻力比来维持机体的液体平衡。因此，脂肪组织间隙液向血液中的动员似乎并非由神经活动引起。
