Khristoforov V S, Kutyshenko V P, Abramov V M, Zav'ialov V P
Institute of Engineering Immunology, Lyubuchany, Moscow Region.
Biofizika. 1997 Nov-Dec;42(6):1180-5.
A comparative study of the conformational and dynamics properties of the ACTH-like linear peptides, sequences of which correspond to amino acid residues 11-20 of the heavy chain of human immunoglobulin G1 Eu, residues 78-85 of human pro-interleukin-1 alpha and site 10-18 of human ACTH, was performed in aqueous solution and dimethylsulfoxide by 1H-NMR spectroscopy at 400 MHz. The peptides were shown to possess an unordered unfolded flexible conformation in aqueous solution. The revealed structural and dynamic features of the peptides are discussed together with biological activity of this class of compounds.
对促肾上腺皮质激素样线性肽的构象和动力学性质进行了比较研究，这些肽的序列分别对应于人免疫球蛋白G1 Eu重链的11 - 20位氨基酸残基、人白细胞介素-1α前体的78 - 85位残基以及人促肾上腺皮质激素的10 - 18位位点。通过400 MHz的1H - NMR光谱在水溶液和二甲基亚砜中对这些肽进行了研究。结果表明，这些肽在水溶液中具有无序的非折叠柔性构象。本文讨论了所揭示的肽的结构和动力学特征以及这类化合物的生物活性。
