Nagasaka T, Nakashima N, Furui A, Wakabayashi T, Yoshida J
Division of Pathology, Clinical Laboratory, Nagoya University Hospital, Japan.
Hum Pathol. 1998 Feb;29(2):190-3. doi: 10.1016/s0046-8177(98)90233-7.
We reported a case of sarcomatous transformation of pituitary adenoma occurring in a 21-year-old woman. She had previously undergone surgery for pituitary adenoma (prolactinoma) 5 years earlier. Since then, she had received only bromocriptine medication therapy. The operation was repeated because of a relapse of the tumors. Histologically, the tumors were composed of adenomatous epithelial nests and fibrosarcomatous spindle cell components intermingled with each other. lmmunohistochemically, adenomatous epithelial cells were stained positively with cytokeratin and prolactin. Fibrosarcomatous spindle cells were stained only with vimentin. The proliferation activity (Ki-67 expression) was much higher in the sarcomatous components than in common pituitary adenoma. p53 immunostaining was also positive in sarcomatous components. This was thought to be the first reported case of sarcomatous transformation of pituitary adenoma not associated with radiation therapy.
我们报告了一例发生在一名21岁女性身上的垂体腺瘤肉瘤样转化病例。她曾在5年前因垂体腺瘤（催乳素瘤）接受过手术。从那时起，她仅接受了溴隐亭药物治疗。由于肿瘤复发，再次进行了手术。组织学上，肿瘤由腺瘤性上皮巢和纤维肉瘤样梭形细胞成分相互混合组成。免疫组织化学检查显示，腺瘤性上皮细胞细胞角蛋白和催乳素染色呈阳性。纤维肉瘤样梭形细胞仅波形蛋白染色呈阳性。肉瘤样成分的增殖活性（Ki-67表达）比普通垂体腺瘤高得多。肉瘤样成分中p53免疫染色也呈阳性。这被认为是首例报道的与放射治疗无关的垂体腺瘤肉瘤样转化病例。
