Higuchi T
Am J Hosp Pharm. 1976 Aug;33(8):795-800.
Recent developments in the area of drug delivery are reviewed. Controlled delivery of drug substances (including controlled-release oral products, the Folkman-Long silastic device and membrane-medicated delivery systems) are discussed. The prodrug approach is illustrated by discussion of the esterification of epinephrine and the production of the dihydro form of 2-PAM (pro-2-PAM). It is suggested that the pharmacist study the release pattern of drug devices and the pharmaceutics of prodrugs in order to maintain his responsibility as the expert on drugs.
本文综述了药物递送领域的最新进展。讨论了药物的控释（包括口服控释产品、福克曼-朗硅橡胶装置和膜介导递送系统）。通过对肾上腺素的酯化和2-PAM（前-2-PAM）二氢形式的制备的讨论，阐述了前药方法。建议药剂师研究药物装置的释放模式和前药的药剂学，以履行其作为药物专家的职责。
