Rameshkumar K
Department Pathology, St. John's Medical College, Bangalore, Karnataka State, India.
Indian J Cancer. 1997 Sep;34(3):107-10.
Epidemiological studies indicate an association between reproductive hormonal factors and colon cancers. The present study was undertaken to evaluate the influence of hormonal variations of the menstrual cycle on the mucin histochemistry of normal colonic mucosa and to analyse its significance in relation to colon cancers.
Fifty three specimens of colon from both 33 reproductive age group females and 20 postmenopausal females were analysed for mucin histochemistry.
An increase in the total mucin content was observed in the late progesterone phase with an increase in the sialomucin fraction.
A postulated mechanism for an estrogenic effect include an increased production of bile acids which may act as either promoter or carcinogen in colonic cancers. The cyclical variations of colonic epithelial mucins indicate a sustained estrogen effect is not possible. Hence it is suggested--the regular menstrual cycles play a protective role and some colon cancers may be hormone induced/dependent.
流行病学研究表明生殖激素因素与结肠癌之间存在关联。本研究旨在评估月经周期激素变化对正常结肠黏膜黏蛋白组织化学的影响，并分析其与结肠癌相关的意义。
对33名育龄期女性和20名绝经后女性的53份结肠标本进行黏蛋白组织化学分析。
在孕酮后期观察到总黏蛋白含量增加，同时唾液黏蛋白部分增加。
雌激素作用的一种假定机制包括胆汁酸生成增加，胆汁酸在结肠癌中可能充当促进剂或致癌物。结肠上皮黏蛋白的周期性变化表明持续的雌激素作用是不可能的。因此，有人提出——规律的月经周期起保护作用，一些结肠癌可能是激素诱导/依赖的。
