Tokunaga N, Sadahiro S, Yasuda S, Mukai M, Ishida H, Kimura T, Suzuki T, Ishikawa K, Iwase H, Kameya T, Tajima T, Makuuchi H
Dept. of Surgery, Tokai University School of Medicine.
Gan To Kagaku Ryoho. 1998 Feb;25(3):353-7.
Thymidine phosphorylase (TdRPase) is an enzyme involved in the pyrimidine metabolism. It was reported that many cancers contained higher levels of TdRPase than normal tissues. And TdRPase has been reported to be identical with the platelet-derived endothelial cell growth factor. To clarify the distribution of TdRPase in primary and metastatic colorectal cancer, we carried out immunohistochemical staining of formalin-fixed specimens. We investigated 35 primary colorectal cancers resected surgically, 27 hepatic metastases and 8 lung metastases from colorectal carcinoma. TdRPase was highly expressed in primary colorectal cancer with lung metastases (100.0%) and surgically resected lung metastases cancer (87.5%). The staining correspondence between primary colorectal cancer and metastases was 19 cases (70.4%) in the liver metastases and 7 cases (87.5%) in the surgically resected lung metastases. The above results suggested that immunohistochemical staining for primary colorectal cancer may provide information about the sensitivity of metastases to the chemotherapy.
胸苷磷酸化酶（TdRPase）是一种参与嘧啶代谢的酶。据报道，许多癌症组织中TdRPase的水平高于正常组织。并且据报道TdRPase与血小板衍生的内皮细胞生长因子相同。为了阐明TdRPase在原发性和转移性结直肠癌中的分布情况，我们对福尔马林固定的标本进行了免疫组织化学染色。我们研究了35例手术切除的原发性结直肠癌、27例肝转移瘤和8例结直肠癌肺转移瘤。TdRPase在伴有肺转移的原发性结直肠癌（100.0%）和手术切除的肺转移癌（87.5%）中高表达。原发性结直肠癌与转移瘤之间的染色一致性在肝转移中为19例（70.4%），在手术切除的肺转移中为7例（87.5%）。上述结果表明，对原发性结直肠癌进行免疫组织化学染色可能为转移瘤对化疗的敏感性提供信息。
