Kadkol S S, Brody J R, Epstein J I, Kuhajda F P, Pasternack G R
Johns Hopkins University School of Medicine, Baltimore, Maryland.
Prostate. 1998 Feb 15;34(3):231-7. doi: 10.1002/(sici)1097-0045(19980215)34:3<231::aid-pros11>3.0.co;2-f.
pp32 is a differentiation-regulated nuclear phosphoprotein that is highly expressed in many cancers, but is restricted to self-renewing and long-lived normal cell populations. During murine embryogenesis, pp32 is expressed in primitive cell populations, diminishing as tissues terminally differentiate. Functionally, pp32 confers resistance to programmed cell death and, paradoxically, inhibits transformation mediated in vitro by a broad range of oncogenes, suggesting that pp32 is a multifunctional molecule with potentially complex activities in cancer.
We studied pp32 expression in prostatic adenocarcinomas and benign prostatic hyperplasia by in situ hybridization.
In benign prostatic tissues, moderate pp32 expression occurs only in the basal cells. This study found elevated pp32 expression in 98% (54/55) of prostatic adenocarcinomas of Gleason score > or = 5 (P < 0.0001).
These results suggest that pp32 may be diagnostically useful and may contribute mechanistically to prostate tumor development. In comparison to other molecular alterations, increased pp32 expression is one of the most frequent events in primary prostate cancer.
pp32是一种受分化调节的核磷蛋白，在许多癌症中高表达，但仅限于自我更新和长寿的正常细胞群体。在小鼠胚胎发育过程中，pp32在原始细胞群体中表达，随着组织终末分化而减少。在功能上，pp32赋予对程序性细胞死亡的抗性，并且矛盾的是，抑制多种癌基因在体外介导的转化，这表明pp32是一种在癌症中具有潜在复杂活性的多功能分子。
我们通过原位杂交研究了pp32在前列腺腺癌和良性前列腺增生中的表达。
在良性前列腺组织中，中等水平的pp32表达仅出现在基底细胞中。本研究发现，在Gleason评分≥5的前列腺腺癌中，98%（54/55）的病例pp32表达升高（P<0.0001）。
这些结果表明，pp32可能具有诊断价值，并可能在机制上促进前列腺肿瘤的发展。与其他分子改变相比，pp32表达增加是原发性前列腺癌中最常见的事件之一。
