Jokinen J, Peters U, Mäki M, Miettinen A, Collin P
Tampere University Hospital, Finland.
J Clin Gastroenterol. 1998 Jan;26(1):23-6. doi: 10.1097/00004836-199801000-00007.
Eighty-two consecutive patients with oral mucosal disorders were screened for celiac sprue with serum immunoglobulin A (IgA)-class endomysial and gliadin antibodies. In positive cases the diagnosis of celiac sprue was established by duodenal biopsy. Four patients were positive for endomysial antibodies and 22 for gliadin antibodies. Four (4.9%) patients were found to have celiac sprue: three of them by screening and one was previously diagnosed. Endomysial antibodies were present in all three newly diagnosed patients with celiac sprue, and gliadin antibodies were present in one. Sixteen of 22 patients positive for gliadin antibodies underwent small bowel biopsy, and 15 had normal mucosa. Patients with chronic oral mucosal disorders and a positive endomysial antibody test may suffer from celiac sprue. By contrast, gliadin antibodies were very prevalent even in the absence of celiac sprue.
对82例连续性口腔黏膜疾病患者进行了血清免疫球蛋白A（IgA）类肌内膜和麦醇溶蛋白抗体检测，以筛查乳糜泻。阳性病例通过十二指肠活检确诊乳糜泻。4例患者肌内膜抗体呈阳性，22例患者麦醇溶蛋白抗体呈阳性。4例（4.9%）患者被发现患有乳糜泻：其中3例通过筛查发现，1例先前已被诊断。所有3例新诊断的乳糜泻患者均存在肌内膜抗体，1例存在麦醇溶蛋白抗体。22例麦醇溶蛋白抗体呈阳性的患者中有16例接受了小肠活检，15例黏膜正常。慢性口腔黏膜疾病且肌内膜抗体检测呈阳性的患者可能患有乳糜泻。相比之下，即使在没有乳糜泻的情况下，麦醇溶蛋白抗体也非常普遍。
