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调节T细胞中白细胞介素-4表达的基因。

Genes that regulate interleukin-4 expression in T cells.

作者信息

Szabo S J, Glimcher L H, Ho I C

机构信息

Harvard School of Public Health, Department of Cancer Biology, Boston, MA 02115, USA.

出版信息

Curr Opin Immunol. 1997 Dec;9(6):776-81. doi: 10.1016/s0952-7915(97)80177-x.

DOI:10.1016/s0952-7915(97)80177-x
PMID:9492977
Abstract

Interleukin-4 is an immunomodulatory cytokine which plays a central role in the regulation of allergic and atopic immune responses. Significant progress has been made in gaining a detailed understanding of the transcriptional regulation of the interleukin-4 gene. The recent identification and characterization of several key transcription factors has helped to elucidate the molecular mechanisms of T helper cell cytokine gene expression.

摘要

白细胞介素-4是一种免疫调节细胞因子，在过敏性和特应性免疫反应的调节中起核心作用。在深入了解白细胞介素-4基因的转录调控方面已取得重大进展。最近对几种关键转录因子的鉴定和表征有助于阐明辅助性T细胞细胞因子基因表达的分子机制。

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