Tung K S, Lou Y H, Garza K M, Teuscher C
Department of Pathology, University of Virginia, Charlottesville 22908, USA.
Curr Opin Immunol. 1997 Dec;9(6):839-45. doi: 10.1016/s0952-7915(97)80187-2.
Investigation of the versatile models for autoimmunity of the ovary and other selected organs has contributed to our understanding of the following aspects of autoimmunity: the mechanism of T cell molecular mimicry; T-->B epitope spreading, as a basis for autoantibody diversification, and as a link between organ-specific and systemic autoimmunity; the localization of genetic loci potentially influencing multiple autoimmune diseases; and the elucidation of regulatory T cells as a component of physiological self tolerance.
对卵巢及其他选定器官自身免疫的通用模型进行研究，有助于我们理解自身免疫的以下几个方面：T细胞分子模拟机制；T→B表位扩展，作为自身抗体多样化的基础，以及器官特异性自身免疫和全身性自身免疫之间的联系；可能影响多种自身免疫性疾病的基因位点定位；以及阐明调节性T细胞作为生理性自身耐受的一个组成部分。
