Hayday A, Geng L
Dept of Molecular, Cell and Developmental Biology, Yale University, New Haven, CT 06511, USA.
Curr Opin Immunol. 1997 Dec;9(6):884-9. doi: 10.1016/s0952-7915(97)80193-8.
Gamma delta cells are attractive candidates for mediators of autoimmune disease. They can expand in germ-free mice, probably through recognition of autoantigens, and gamma delta-cell-deficient mice, unlike mice deficient in alpha beta T cells or B cells, show no severe defects in the immune response to foreign antigen challenge. A capacity of gamma delta cells to effect or regulate tissue damage is also plausible, given their ready localization to tissues, and their myriad of effector functions. Added to this, attempts to reconstruct the physiological course of autoimmune diseases with only autoreactive alpha beta T cells seem invariably to fall short for lack of other unidentified players. Gamma delta cells and their putative ligands have been linked to autoimmune conditions, and recent experiments confirm that gamma delta cells play a significant role in autoimmune disease in vivo.
γδ细胞是自身免疫性疾病介导因子的有吸引力的候选者。它们可以在无菌小鼠中扩增，可能是通过识别自身抗原，并且与αβT细胞或B细胞缺陷的小鼠不同，γδ细胞缺陷的小鼠在对外源抗原攻击的免疫反应中没有严重缺陷。鉴于γδ细胞易于定位于组织及其众多的效应功能，它们具有影响或调节组织损伤的能力也是合理的。此外，仅用自身反应性αβT细胞重建自身免疫性疾病的生理过程的尝试似乎总是因缺乏其他未鉴定的参与者而失败。γδ细胞及其假定的配体已与自身免疫性疾病相关联，最近的实验证实γδ细胞在体内自身免疫性疾病中起重要作用。
