1,3,2-二氧磷杂环戊烷2-氧化物衍生物对乙酰胆碱酯酶的抑制作用
Inhibition of acetylcholinesterase by derivatives of 1,3,2-dioxaphosphorinane 2-oxide.
作者信息
Coult D B
出版信息
Biochem J. 1976 Jun 1;155(3):717-9. doi: 10.1042/bj1550717.
Abstract
Cholinesterases are inhibited by 2-fluoro-1,3,2-dioxaphosphorinane 2-oxide by a mechanism that involves a slow association step followed by a very slow phosphorylation step. No phosphorylation step was observed for the interaction between acetylcholinesterase and 2-S-[2'-(NN-diethylamino)ethyl]thio-1,3,2-dioxaphosphorinane 2-oxide.
摘要
胆碱酯酶被2-氟-1,3,2-二氧磷杂环己烷2-氧化物抑制，其机制涉及一个缓慢的结合步骤，随后是一个非常缓慢的磷酸化步骤。对于乙酰胆碱酯酶与2-S-[2'-(N,N-二乙氨基)乙基]硫代-1,3,2-二氧磷杂环己烷2-氧化物之间的相互作用，未观察到磷酸化步骤。
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引用本文的文献
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