外显子重复对内含子和外显子相位分布的影响。

Influence of exon duplication on intron and exon phase distribution.

作者信息

Fedorov A, Fedorova L, Starshenko V, Filatov V, Grigor'ev E

机构信息

Department of Molecular Basis of Human Genetics, Academy of Sciences of Russia, Moscow, Russia.

出版信息

J Mol Evol. 1998 Mar;46(3):263-71. doi: 10.1007/pl00006302.

DOI:10.1007/pl00006302

PMID:9493351

Abstract

Nonrandomness in the intron and exon phase distributions in a sample of 305 human genes has been found and analyzed. It was shown that exon duplications had a significant effect on the exon phase nonrandomness. All of the nonrandomness is probably due to both the processes of exon duplication and shuffling. A quantitative estimation of exon duplications in the human genome and their influence on the intron and exon phase distributions has been analyzed. According to our estimation, the proportion of duplicated exons in the human genome constitutes at least 6% of the total. Generalizing the particular case of exon duplication to the more common event of exon shuffling, we modeled and analyzed the influence of exon shuffling on intron phase distribution.

摘要

在305个人类基因样本中，已发现并分析了内含子和外显子相位分布的非随机性。结果表明，外显子重复对外显子相位的非随机性有显著影响。所有的非随机性可能都归因于外显子重复和重排过程。已对人类基因组中外显子重复及其对内含子和外显子相位分布的影响进行了定量估计。根据我们的估计，人类基因组中重复外显子的比例至少占总数的6%。将外显子重复的特殊情况推广到更常见的外显子重排事件，我们对其进行建模并分析了外显子重排对内含子相位分布的影响。