舍曲林在体内不抑制细胞色素P450 3A介导的药物代谢。
Sertraline does not inhibit cytochrome P450 3A-mediated drug metabolism in vivo.
作者信息
Preskorn S H, Alderman J, Greenblatt D J, Horst W D
机构信息
Psychiatric Research Institute, Wichita, KS 67214, USA.
出版信息
Psychopharmacol Bull. 1997;33(4):659-65.
PMID:9493476
Abstract
The in vivo effect of sertraline on oxidative drug metabolism mediated by cytochrome P450 (CYP) 3A was assessed by coadministration with alprazolam, carbamazepine, and terfenadine in three separate studies. Sertraline at doses of 50 to 200 mg/day for 10 to 20 days did not alter the pharmacokinetics of these CYP3A substrates/drugs.
摘要
在三项独立研究中，通过与阿普唑仑、卡马西平和特非那定联合给药，评估了舍曲林对细胞色素P450（CYP）3A介导的氧化药物代谢的体内效应。舍曲林剂量为50至200毫克/天，持续10至20天，并未改变这些CYP3A底物/药物的药代动力学。
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