Preskorn S H, Alderman J, Greenblatt D J, Horst W D
Psychiatric Research Institute, Wichita, KS 67214, USA.
Psychopharmacol Bull. 1997;33(4):659-65.
The in vivo effect of sertraline on oxidative drug metabolism mediated by cytochrome P450 (CYP) 3A was assessed by coadministration with alprazolam, carbamazepine, and terfenadine in three separate studies. Sertraline at doses of 50 to 200 mg/day for 10 to 20 days did not alter the pharmacokinetics of these CYP3A substrates/drugs.
在三项独立研究中，通过与阿普唑仑、卡马西平和特非那定联合给药，评估了舍曲林对细胞色素P450（CYP）3A介导的氧化药物代谢的体内效应。舍曲林剂量为50至200毫克/天，持续10至20天，并未改变这些CYP3A底物/药物的药代动力学。
