Kouri E M, Halbreich U
Biological Psychiatry Laboratory, McLean Hospital/Harvard Medical School, Belmont, MA, USA.
Psychopharmacol Bull. 1997;33(4):767-70.
Three to eight percent of women of reproductive age suffer from dysphoric premenstrual disorder (PMS). Although the exact pathophysiology of this disorder is not known, serotonergic dysregulation appears to be involved. In this article, we review and summarize the current data on changes in serotonergic parameters in women with dysphoric PMS and emphasize the distinction between state-related abnormalities which are present only during the symptomatic late-luteal phase and trait abnormalities which are present even during non-symptomatic phases of the menstrual cycle. The notion of diversified serotonergic systems that are selectively affected by fluctuations in gonadal hormones is discussed in the context of PMS as well as other dysphorias.
3%至8%的育龄女性患有经前烦躁障碍（PMS）。尽管这种疾病的确切病理生理学尚不清楚，但血清素调节异常似乎与之相关。在本文中，我们回顾并总结了目前关于经前烦躁障碍女性血清素参数变化的数据，并强调仅在有症状的黄体晚期出现的与状态相关的异常和即使在月经周期无症状阶段也存在的特质异常之间的区别。在经前烦躁障碍以及其他烦躁症的背景下，讨论了性腺激素波动选择性影响的多样化血清素系统的概念。
