Wright D, Poller L, Thomson J M, Sidebotham A, Hirst C F, Hirsch P
Department of Pathological Sciences, The University of Manchester, UK.
Thromb Haemost. 1998 Feb;79(2):328-30.
A longitudinal study of 21 pregnant women has been undertaken using a variety of factor VII assays, including factor VIIa, to investigate the increase of factor VIIc. All assays demonstrated significant rises (p <0.001), most marked for factor VIIa (82%) and factor VIIc rabbit (81%). Smaller rises were seen for factor VIIc bovine (50%) and VII antigen (40%). Three indirect measures of activity state, factor VIIc rabbit:antigen, bovine:antigen and bovine:rabbit, provided conflicting data. Factor VIIa:antigen showed a significant increase of 36% (p <0.001). Within individual pregnancies the change in factor VIIc rabbit and antigen correlated with maternal weight gain (p < 0.05). Two activity state measures, bovine:rabbit and bovine:antigen, showed negative correlation with birthweight. The increases in both zymogen and in activity state appear to contribute to the factor VIIc rise. The extent of this rise appears to be influenced by maternal weight gain. Increased factor VII activation is associated with reduced foetal growth.
对21名孕妇进行了一项纵向研究，采用了包括因子VIIa在内的多种因子VII检测方法，以研究因子VIIc的升高情况。所有检测均显示出显著升高（p<0.001），其中因子VIIa（82%）和兔因子VIIc（81%）的升高最为明显。牛因子VIIc（50%）和VII抗原（40%）的升高幅度较小。三种活性状态的间接测量指标，即兔因子VIIc:抗原、牛因子VIIc:抗原和牛因子VIIc:兔因子VIIc，提供了相互矛盾的数据。因子VIIa:抗原显著增加了36%（p<0.001）。在个体妊娠中，兔因子VIIc和抗原的变化与孕妇体重增加相关（p<0.05）。两种活性状态测量指标，即牛因子VIIc:兔因子VIIc和牛因子VIIc:抗原，与出生体重呈负相关。酶原和活性状态的增加似乎都导致了因子VIIc的升高。这种升高的程度似乎受孕妇体重增加的影响。因子VII激活增加与胎儿生长受限有关。
