Herrmann S M, Poirier O, Nicaud V, Ruidavets J B, Evans A, Arveiler D, Luc G, Bara L, Cambien F
Institut National de la Santé et de la Recherche Médicale SC7, Paris, France.
Thromb Haemost. 1998 Feb;79(2):359-61.
The histidin-rich glycoprotein (HRG) may contribute to coronary heart disease as a consequence of its possible thrombophilic properties. To test this hypothesis we have investigated the Pro186/Ser polymorphism of the HRG gene, which is known to strongly affect plasma HRG levels, in a large multicenter case-control study of myocardial infarction (MI). The results failed to demonstrate any association between the polymorphism and MI or angiographically assessed coronary stenosis.
富含组氨酸的糖蛋白（HRG）因其可能的血栓形成倾向特性，可能与冠心病有关。为验证这一假说，我们在一项关于心肌梗死（MI）的大型多中心病例对照研究中，调查了HRG基因的Pro186/Ser多态性，已知该多态性会强烈影响血浆HRG水平。结果未能证明该多态性与MI或血管造影评估的冠状动脉狭窄之间存在任何关联。
