多发性硬化症及其他神经疾病患者脑脊液和血清中针对富含轴膜成分的抗体。

Antibodies to the axolemma-enriched fraction in the cerebrospinal fluid and serum of patients with multiple sclerosis and other neurological diseases.

作者信息

Rawes J A, Calabrese V P, Khan O A, DeVries G H

机构信息

Department of Biochemistry and Molecular Biophysics, Medical College of Virginia, Richmond 23298-0614, USA.

出版信息

Mult Scler. 1997 Dec;3(6):363-9. doi: 10.1177/135245859700300601.

DOI:10.1177/135245859700300601

PMID:9493635

Abstract

Antibodies to an axolemma-enriched fraction (AEF) antigen have been detected in the cerebrospinal fluid (CSF) and serum of patients with Multiple Sclerosis (MS) using an enzyme-linked immunosorbent assay (ELISA). A marginal elevation (P < 0.08) of anti-AEF IgG was found in MS CSF when compared with OND samples. When CSF was diluted to a standardized IgG concentration, the anti-AEF IgG level in MS CSF was significantly elevated (P=0.007) when compared to OND CSF. MS serum was also found to contain a significantly higher level (P < 0.001) of anti-AEF IgG when compared to OND serum using the ELISA technique.

摘要

采用酶联免疫吸附测定（ELISA）法，在多发性硬化症（MS）患者的脑脊液（CSF）和血清中检测到了针对轴膜富集组分（AEF）抗原的抗体。与其他神经系统疾病（OND）样本相比，MS患者脑脊液中抗AEF IgG水平略有升高（P < 0.08）。当将脑脊液稀释至标准化IgG浓度时，与OND脑脊液相比，MS脑脊液中的抗AEF IgG水平显著升高（P = 0.007）。使用ELISA技术还发现，与OND血清相比，MS血清中抗AEF IgG水平也显著更高（P < 0.001）。