聚（甲基丙烯酸2-羟乙酯-嵌段-4-双（三甲基硅基）甲基苯乙烯）水凝胶具有异常高的自由水含量，可使血小板相互作用降至最低。

Minimized platelet interaction with poly(2-hydroxyethyl methacrylate-block-4-bis(trimethylsilyl)methylstyrene) hydrogel showing anomalously high free water content.

作者信息

Kataoka K, Ito H, Amano H, Nagasaki Y, Kato M, Tsuruta T, Suzuki K, Okano T, Sakurai Y

机构信息

Department of Materials Science and Technology, Science University of Tokyo, Noda, Japan.

出版信息

J Biomater Sci Polym Ed. 1998;9(2):111-29. doi: 10.1163/156856298x00460.

DOI:10.1163/156856298x00460

PMID:9493840

Abstract

Novel hydrophilic-hydrophobic block copolymers - poly(2-hydroxyethyl methacrylate-block-4-bis(trimethylsilyl)methylstyrene) (poly(HEMA-block-BSMS) or BH polymer) - were prepared as materials potentially useful for blood-contacting devices. Among the BH(X) series including poly(HEMA) itself, platelet adhesion and activation are minimum on the surface of BH(10), the block copolymer composed of 10 mol% of the hydrophobic segment. The unique physicochemical characteristics of BH(10) such as the high free water content and the increased mobility of PHEMA segments seem to play an important role in the prevention of platelet adhesion and activation. The water content of BH(10) was twice that of poly(HEMA) itself, even in the presence of 10 mol% of the hydrophobic moiety [poly(BSMS)]. Further, an anomalous increase in free water content was observed for the BH(10) sample measured by DSC. The glass transition temperature of BH(10) in the dry state was determined to be c. 10 degrees C, which was much lower than that observed for each of the homopolymers (c.f.: Tg [poly(HEMA)] = 70 degrees C; Tg [poly(BSMS)] = 160 degrees C), suggesting an increased mobility of tethered PHEMA segments in the BH(10) film.

摘要

新型亲水-疏水嵌段共聚物——聚（甲基丙烯酸2-羟乙酯-嵌段-4-双（三甲基硅基）甲基苯乙烯）（聚（HEMA-嵌段-BSMS）或BH聚合物）——被制备出来，作为可能用于血液接触装置的材料。在包括聚（HEMA）本身的BH（X）系列中，在由10摩尔%疏水链段组成的嵌段共聚物BH（10）表面，血小板的粘附和活化最少。BH（10）独特的物理化学特性，如高自由水含量和PHEMA链段流动性增加，似乎在防止血小板粘附和活化中起重要作用。即使存在10摩尔%的疏水部分[聚（BSMS）]，BH（10）的水含量也是聚（HEMA）本身的两倍。此外，通过差示扫描量热法（DSC）测量的BH（10）样品的自由水含量出现异常增加。BH（10）在干燥状态下的玻璃化转变温度测定为约10℃，远低于每种均聚物观察到的温度（参考：聚（HEMA）的玻璃化转变温度Tg = 70℃；聚（BSMS）的玻璃化转变温度Tg = 160℃），这表明BH（10）薄膜中连接的PHEMA链段的流动性增加。