多巴胺D2受体对GABA(A)受体表达的影响可能会改变促黑素细胞激素释放肽的释放。

Dopamine D2 receptor effects on GABA(A) receptor expression may modify melanotrope peptide release.

作者信息

Sands S A, de Blas A L, Chronwall B M

机构信息

School of Biological Sciences, University of Missouri-Kansas City, 64110, USA.

出版信息

Peptides. 1998;19(2):397-401. doi: 10.1016/s0196-9781(97)00381-1.

DOI:10.1016/s0196-9781(97)00381-1

PMID:9493875

Abstract

Stimulation of melanotrope dopamine D2 receptors decreases mitotic rate, calcium channel activity, and the biosynthesis of several proteins. This study demonstrates that D2 receptor activation also affects GABA(A) receptor beta2/beta3 subunit immunoreactivity. Following chronic treatment with haloperidol, a D2 receptor antagonist, GABA(A) receptor immunoreactivity increased, whereas it decreased after chronic treatment with bromocriptine, a dopamine D2 receptor agonist. Thus, these data indicate that D2 function regulates GABA(A) receptor expression in melanotropes, a mechanism by which peptide release may be modified.

摘要

刺激促黑素细胞多巴胺D2受体可降低有丝分裂率、钙通道活性以及几种蛋白质的生物合成。本研究表明，D2受体激活还会影响GABA(A)受体β2/β3亚基的免疫反应性。用D2受体拮抗剂氟哌啶醇长期治疗后，GABA(A)受体免疫反应性增加，而用多巴胺D2受体激动剂溴隐亭长期治疗后则降低。因此，这些数据表明，D2功能调节促黑素细胞中GABA(A)受体的表达，这可能是一种调节肽释放的机制。