Castelli M, Baggio G, Ruberto A I, Malagoli M, Casolari C, Rossi T, Galatulas I
Department of Biomedical Sciences, University of Modena, Italy.
Anticancer Res. 1997 Nov-Dec;17(6D):4339-44.
The most widely-known anti-tumor drugs often induce marked immunosuppression which can give rise to one or more sepses. Anti-infection measures immediately applied can sometimes prove largely ineffective or even useless, the patient dying not as a result of the spread of the tumour but as a direct consequence of opportunistic infection. We postulate that antagonism between anti-tumour and antimicrobial drugs may also play an important part in this. By way of illustration of this hypothesis, we have studied the action of a number of known inhibitors of peptidoglycan synthesis and of DNA-gyrases on certain strains of Gram-positive and Gram-negative microorganisms cultured in medium containing various concentrations of some of the best-known anti-tumour antimetabolites. The experimental data show that antimicrobial and anti-tumour drugs can sometimes induce synergic or indifferent chemotherapeutic interactions with many bacteria, while in others the effect is antagonistic. In practice, the action of the drugs could lead to bacterial selectivity, which, in conjunction with immunosuppression and the presence of resistant strains, could favour the evolution of opportunistic infection.
最广为人知的抗肿瘤药物常常会引发显著的免疫抑制，进而可能导致一种或多种脓毒症。立即采取的抗感染措施有时会证明效果不佳甚至毫无用处，患者并非死于肿瘤的扩散，而是死于机会性感染的直接后果。我们推测抗肿瘤药物与抗菌药物之间的拮抗作用在这方面可能也起到了重要作用。为了说明这一假设，我们研究了多种已知的肽聚糖合成抑制剂和DNA旋转酶抑制剂对在含有不同浓度某些最知名抗肿瘤抗代谢物的培养基中培养的某些革兰氏阳性和革兰氏阴性微生物菌株的作用。实验数据表明，抗菌药物和抗肿瘤药物有时会与许多细菌产生协同或无明显作用的化疗相互作用，而在其他情况下则会产生拮抗作用。在实际应用中，药物的作用可能导致细菌选择性，这与免疫抑制和耐药菌株的存在相结合，可能会促使机会性感染的发展。
