el Attar T M, Virji A S
Hormone Research Laboratory, University of Missouri-Kansas City, Schools of Dentistry and Medicine 64108, USA.
Anticancer Res. 1997 Nov-Dec;17(6D):4399-402.
The effect of indomethacin, cisplatin and delta 12-prostaglandin J2 (PGJ2) on the inhibition of cell growth and DNA Synthesis (i.e. cell proliferation), was evaluated in vitro on human oral squamous carcinoma cells(SCC-25). The rank order of their inhibitory potency at 10(-5) M was delta 12-PGJ2 > cisplatin > indomethacin. However, delta 12-PGJ2 at 10(-7) and 10(-6) M induced a significant stimulatory effect on cell growth as well as DNA synthesis. The sefindings suggest that delta 12-PGJ2 is a promising novel chemotherapeutic agent for oral cancer and potential candidate for future clinical investigations.
在体外对人口腔鳞状癌细胞（SCC - 25）评估了吲哚美辛、顺铂和δ12 - 前列腺素J2（PGJ2）对细胞生长抑制和DNA合成（即细胞增殖）的影响。在10^(-5) M浓度下，它们抑制效力的排序为δ12 - PGJ2 > 顺铂 > 吲哚美辛。然而，10^(-7) M和10^(-6) M的δ12 - PGJ2对细胞生长以及DNA合成产生了显著的刺激作用。这些发现表明，δ12 - PGJ2是一种有前景的新型口腔癌化疗药物，也是未来临床研究的潜在候选药物。
