Flaherty L, Jarvis A, Harris M, Tyrrell V, Smith A
Department of Cytogenetics, Royal Alexandra Hospital, Westmead, New South Wales, Australia.
Cancer Genet Cytogenet. 1998 Mar;101(2):134-7. doi: 10.1016/s0165-4608(97)00254-9.
A 72-year-old man with increased monocytes and eosinophils in the bone marrow was found to have an isochromosome, i(14q), as the sole abnormality on bone-marrow cytogenetics. Follow-up over 12 months with repeat cytogenetic testing of bone marrow specimens on three further occasions showed an additional abnormality consisting of an apparently balanced translocation, t(6;21)(p21.1; q22). This abnormality, together with other features, indicated disease progression. A review of seven reported cases of i(14q) revealed limited follow-up information.
一名72岁男性，骨髓中单核细胞和嗜酸性粒细胞增多，骨髓细胞遗传学检查发现唯一异常为14号等臂染色体，i(14q)。在随后的12个月里，又对骨髓标本进行了3次细胞遗传学检测，结果显示出现了另一种异常，表现为明显平衡易位，t(6;21)(p21.1; q22)。这种异常以及其他特征提示疾病进展。对7例报道的i(14q)病例进行回顾后发现，随访信息有限。
