Askenazy F, Candito M, Caci H, Myquel M, Chambon P, Darcourt G, Puech A J
Service de Psychiatrie de l'enfant et de l'adolescent, Fondation Lenval, Nice, France.
Biol Psychiatry. 1998 Feb 1;43(3):188-95. doi: 10.1016/S0006-3223(97)00299-0.
We hypothesized that anorectics with or without bulimic features would differ on impulsivity and indices of central serotoninergic function (high impulsivity being correlated with reduced serotoninergic function).
For all patients impulsivity rating scales and questionnaires detailing severity of eating disorder were assessed, and whole blood serotonin concentration (5-HT), free and total tryptophan (TT) concentrations, and large neutral amino acids (LNAA) were assayed.
Nineteen patients with anorexia nervosa were included, 10 presented associated bulimic features and nine did not. Twelve healthy matched controls were also included. Our hypothesis was not verified. However, tryptophan concentration and the ratio of tryptophan concentration to LNAA allow us to separate controls from anorectics, whereas 5-HT concentration does not. Two significant and positive correlations were found: between impulsivity and anxiety in the total anorectic population, and between anxiety and serotonin in the impulsive group.
All measured peripheral biologic indices except 5-HT concentration may be of interest in this pathology. Impulsivity and anxiety seem to be two personality components involved in anorexia nervosa. This study lead us to the necessity of redefining impulsivity in anorexia nervosa.
我们假设，有或没有暴食特征的厌食症患者在冲动性和中枢5-羟色胺能功能指标方面存在差异（高冲动性与5-羟色胺能功能降低相关）。
对所有患者进行冲动性评定量表和详细描述进食障碍严重程度的问卷调查，并检测全血5-羟色胺浓度（5-HT）、游离和总色氨酸（TT）浓度以及大中性氨基酸（LNAA）。
纳入19例神经性厌食症患者，其中10例有相关暴食特征，9例没有。还纳入了12名健康匹配对照。我们的假设未得到证实。然而，色氨酸浓度以及色氨酸浓度与LNAA的比值能使我们将对照与厌食症患者区分开来，而5-HT浓度则不能。发现了两个显著的正相关：在整个厌食症患者群体中冲动性与焦虑之间，以及在冲动组中焦虑与5-羟色胺之间。
除5-HT浓度外，所有测量的外周生物学指标可能都与这种病理情况有关。冲动性和焦虑似乎是神经性厌食症涉及的两个人格成分。这项研究使我们认识到有必要重新定义神经性厌食症中的冲动性。
