Allos B M
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Infect Dis Clin North Am. 1998 Mar;12(1):173-84. doi: 10.1016/s0891-5520(05)70416-5.
A previously unrecognized sequelum of infection with Campylobacter jejuni, a common cause of gastroenteritis, is Guillain-Barré syndrome (GBS). GBS is the most common cause of acute neuromuscular paralysis; 30% to 40% of cases are preceded by C. jejuni infection. Both patient and bacterial characteristics likely play a role in the pathogenesis of C. jejuni-induced GBS. Molecular mimicry between the LPS of some campylobacters and structures present on the gangliosides of the peripheral nerve may explain how this acute infectious diarrheal illness triggers GBS.
空肠弯曲菌是肠胃炎的常见病因，感染该病菌后会出现一种此前未被认识的后遗症——吉兰-巴雷综合征（GBS）。GBS是急性神经肌肉麻痹最常见的病因；30%至40%的病例在发病前有过空肠弯曲菌感染。患者和细菌的特征可能都在空肠弯曲菌诱发GBS的发病机制中发挥作用。某些弯曲杆菌的脂多糖与周围神经神经节苷脂上的结构之间的分子模拟，或许可以解释这种急性感染性腹泻疾病是如何引发GBS的。
